Best Buy To Shut 50 Stores In Streamlining Effort

TechCrunch's Best Buy tag isn't exactly a heartening place to visit. In the last few months, it "stole Christmas," been "finished," and is now "going out of business." Dire straits indeed for a company that has defied the odds not only against big retail competition but against deadlier online opponents as well for nearly 50 years. But an announcement today seems to give a little weight to the doom and gloom expected from a tech community that views Best Buy as an anachronism. Best Buy will be closing 50 of its big box stores and laying off some 400 people, mostly on the administrative side. Is it rightsizing or just plain attrition?

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Opportunities to Add Hand-Scraped Flooring for Home | Home ...

Demand for hand-scraped hardwood ladders, and seems not soon disappear. If you plan to install new flooring, you get on board with this trend? If yes, scraped the market and the opportunities at hand hardwood now an enormous size, and includes virtually all types of solid and engineered varieties. In addition, there are established or developed and engineered flooring is unfinished or better for your house, what are the options?

Classic and rustic style are both possibilities. Although texture is a driving force behind the demand, so both types have different properties. Classic is smooth, with few brands like structure and character. Rustic, on the other hand, a higher incidence of these visual features of knots, heavy grain mineral strips and the dots on each shelf carefully.

Buyers should look for counterfeiting. Although laminate mimics a scratched and well formed, is an option that used flooring considered a lower quality version. Made from genuine hardwood, is determined by his ailing labels ? all from one machine pressed into the surface.

In itself a troubled board appears, but when installed side by side, see the pattern. A lack of uniformity and repetition is a common destination for hand-scraped hardwood, but despair at the end have the opposite effect.

For authentic products that are structured in style, finish and split with age. Textured often go ?wire brush?, ?hand cut? or ?hand-hewn and rough sawn.? Handmade is the least structured, with a rough surface is modeled, wire brush, indicating that the grain is highlighted, and removed the pin. Hand-hewn and sawn, live on the other hand, his name, as structured, has this man seen as even lines.

Finish creating an illusion of depth. French hemorrhage, characterized by a lower beveled edges used on the darker surface of the joints, and gives a deeper look. Age, with a degree of finish application. Going ?old time-worn? or ?old? This diversity includes aging hardwood and use a dark stain, highlighting cereal or contours.

Pre-scraped products are not the only possibilities for hand scraped spread out there. Hardwood, in fact, looking desperate for the ultimate home uneven with a lack of repetition to create. For custom troubling unfinished hardwood is installed first and then get a professional to give the rustic, rugged character. Although techniques vary, hardwood with antique nails, chains, salted, bleached or confirmation.

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P.F. Chang's to Webcast First Quarter Fiscal ... - AZ Venture Capital

?P.F. Chang's China Bistro, Inc.?(NASDAQ: PFCB) today announced plans to release its first quarter fiscal 2012 financial results at 7:30 a.m. Eastern Time on Tuesday, May 1, 2012. The Company plans to hold a conference call to discuss the results beginning at 8:30 a.m. Eastern Time on the same day.

Investors and interested parties may listen to a live webcast or replay of this call by visiting the Company?s website at www.pfcb.com under the investors section. To listen to the live webcast, please log in at least 15 minutes prior to the call in order to download and install any necessary audio software. An archive of the webcast will also be available shortly after the call.

About P.F. Chang?s

P.F. Chang?s China Bistro, Inc. owns and operates two restaurant concepts in the Asian niche. P.F. Chang?s China Bistro features a blend of high-quality, Chinese-inspired cuisine and American hospitality in a sophisticated, contemporary bistro setting. Pei Wei Asian Diner offers a modest menu of freshly prepared pan-Asian cuisine in a relaxed, warm environment offering attentive counter service and take-out flexibility. In addition, the Company has extended the P.F. Chang's brand to international markets and retail products both of which are operated under licensing agreements.

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Real Estate and Property Investing:MI Inventory Homes List | Real ...

Article Summary:

Real Estate and Property Investing Strategies that work in today?s market using transactional funding, private money and proof of funds letter to profit with short sales and bank owned properties.Good Morning! Today seemed like a good day to start with an inventory listing of property from MI Homes. These properties are usually built but a home builder to show a new customer what they can request in their new?

Article Content:
Good Morning!

Today seemed like a good day to start with an inventory listing of property from MI Homes. These properties are usually built but a home builder to show a new customer what they can request in their new house. MI Homes does build a good property so I thought I?d send this out so everyone can take a look.

If you?re an investor and looking for something safe, MI also has model homes for sale that you can then rent back to the company while they finish selling out their properties.

MI Inventory Homes

They have a few other deals going as well, so give me a call or email to see what their specials are.

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Non-iPad Speaker Dock Says the Kindle Fire's Finally Arrived [Speakers]

It's a rarer occurrence that spotting bigfoot riding the Loch Ness monster, but Grace Digital Audio has just announced a speaker dock designed specifically for the Kindle Fire. You read that right, the FireDock won't even acknowledge the iPad's existence. More »

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Keep Health And Fitness | Health Information and Medical News

There?s a lot persons can perform walking such or jogging in the morning, playing basketball or some other sport with friends but when anyone really wants to have muscles and look lean, the best thing to accomplish can be to enroll and workout in the gym.?
Exactly like taking any medicine, you need to first consult the doctor before undergoing any form of exercise.
Physical exercise is beneficial since it helps maintain and improve ones health from many diseases and premature death. ?It also makes a person feel happier and increases ones self esteem preventing one from falling into depression or anxiety. It has also shown to make someone with a vigorous lifestyle live longer than a one who doesn?t.
The perfect exercise plan should have cardiovascular and weight training exercises.

This helps burn calories and increase the muscle to fat ratio that will increase ones metabolism and make one either gain or lose weight.?
A one who has never worked out before should do it gradually. Doing it too much for the very first time could make one pull a muscle or have an injury which makes it worse. Endurance won?t ever be built in a day and doing it repeatedly will surely be good to the person.
Specializing in certain portion in our bodies may help make it improve. An effective example will the gym and doing a workout more often in a unique area such as the abs may give one a chest pack.?
But beauty is not just about having muscles which is what people can see. Additionally it is about enhancing the sweetness within.?
Here are some things one can perform everyday to remain beautiful and healthy;?
?Reading books and other reading material more often keeps the mind sharp exactly like working out keeps our bodies in shape.
Work no matter what kind it?s produces stress. One can reduce this by taking the time out to do something special like lying in the hot tub, shopping or watching a movie. Studies have shown it?s reliever and helps one from looking haggardly.
Pollution is something people cannot control given the scale of the problem. When one goes out, it is best to put some type of protection such as beauty products that contain antioxidants that protect the skin from damage. There are also other beauty products available and choosing the right one with the assistance ?of a dermatologist may help the person.
Another way to keep healthy is to give up some vices. Most people smoke and drink. Smoking has been proven to cause lung cancer and other diseases as well complications for women giving birth. Excessive drinking has also shown to do the same.?
For people who don?t smoke, it?s best to keep away from individuals who do since studies have shown that nonsmokers are at risk of developing cancer due to secondary smoke inhalation.
Lastly, it is best to always start the day with a positive outlook. As studies have shown that exercise makes anyone feel happier, smiling produces the same effect. A smile can do a great deal and it is contagious in a positive sense. It brightens your day of not just one but others as well.

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Revel: Spanning the Culinary Gamut | Food & Drink | Atlantic City ...

From a casual lunch-truck approach to modern Mexican to the finest in French-inspired cuisine, ?Revel will have the entire dining spectrum covered.

ATLANTIC CITY ? Despite our early spring date, and extraordinarily warm weather, there?s a Christmas Eve feel in the air around Atlantic City.?

For food folks, at least, counting with eager anticipation the precious few days until Revel Casino provides our region with an exciting array of new dining options. Leading the charge is Philadelphia?s Jose Garces ? with versions of flagship facility Amada, Village Whiskey and Distrito Cantina ? expanding his culinary empire eastward.?

Amada, described as ?Andalusian tapas? will, like its Philly brethren, focus on earthy Mediterranean flavors. Items like chorizo and clams, crab-stuffed piquillo peppers or baby squid grilled and garnished with a sort of deconstructed chimichurri, lemon, garlic and parsley.?

For the adventurous, Amada suggests cochinillo asado: whole suckling pig brined and slow-roasted for 36 hours. Be forewarned; bring friends and pre-order in advance. Village Whiskey, open in Philly since 2009, serves casual, tavern fare like burgers, oysters, duck fat French fries and pickled truffle/lemon artichokes.?

Along with an extensive selection ? more than 80 kinds ? of the eponymous beverage, in bourbon, scotch and rye formats.?

Distrito Cantina will present a casual, street truck-style approach to modern Mexican. Described as a ?take out window inspired by the uber-popular Guapos Taco Truck in Philly? their bill of fare includes favorites like tacos, guac and chips, enchiladas and seviche. Which brings us to a triad of restaurants from NYC?s LDV Hospitality Group.?

American Cut will fill the requisite steak house slot at Revel. A native New Yorker with deep family roots in the industry, Marc Forgione is also the youngest American-born chef to earn a prestigious Michelin star in three consecutive years (2010-2012) for his namesake facility Restaurant Marc Forgione.?

Recruited by legendary French chef Laurent Tourondel to open his seminal BLT Prime steak house in New York, Forgione went on to help develop the BLT brand across the country. Worth noting: BLT Prime received the highest ranking ? 27 out of a possible 30 ?of any steak house in New York history from Zagat.?

Insider Tip: Wondering about the name ?American Cut?? It?s homage to Forgione?s chef father, Larry, whose own iconic restaurant was called ?An American Place.? Oh, and by the way, Forgione has been an alumnus of Food Network?s Iron Chef America since winning that yearly competition in 2010.?

Azure by Allegretti brings a unique cooking style ? coastal cuisine of the French/Italian Riviera ? to southern New Jersey shores. Headed by Alain Allegretti, a native of chic resort town Nice, Azure will blend views of the Atlantic outside with those of an exhibition kitchen within.?

Diners should expect traditional fare like oysters and whole grilled or roasted fish, much of it sourced locally, filtered through Allegretti?s French technique and Italian heritage.?

Lugo, the second LDV operation, will serve Italian comfort classics ? house-made pasta, mozzarella, and meatballs ? in a caf? environment. Heartier fare too, like steaks and chops, including the classic double-cut porterhouse, steak Fiorentina.?

Open for lunch and dinner, Lugo is the second outpost of New York?s Lugo Caffe.?

COMMENTS

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TheDude said...
Mandy Moore is pretty smokin. I wish I was cool enough to date her. Does anybody know how I can get her number?

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' + comment }); numDiv.inject( commentLi ); commentPar.inject( commentLi ); commentLi.inject( commentUl ); } else { msgPar.set( 'html', 'Comment has been sent for approval' ); } } } function displayNewComment() { var msgP = document.getElementById("msg"); msgP.innerHTML = "Thank you for your submission. Your comment has been added below."; if(comment != "") { if(!flagged) { var commentSection = document.getElementById("ajaxSection"); var commentDiv = document.createElement("div"); var timeStamp = 'Mar 29, 2012 at 10:30PM'; commentDiv.innerHTML = ''; commentSection.appendChild(commentDiv); } } } function validateCommentForm(form){ var fieldEmail = document.getElementById("field.email"); var fieldName = document.getElementById("field.name"); var nameValue = fieldName.value; var emailValue = fieldEmail.value; var filter = /^([a-zA-Z0-9_\.\-])+\@(([a-zA-Z0-9\-])+\.)+([a-zA-Z0-9]{2,4})+$/; if (filter.test(emailValue)) { var fieldBody = document.getElementById("field.body") var bodyValue = fieldBody.value; bodyValue = bodyValue.replace(/&/g,"&"); bodyValue = bodyValue.replace(/,"/g,">"); bodyValue = bodyValue.replace(/\r\n/g,"
"); bodyValue = bodyValue.replace(/\n/g,"
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"); fieldBody.value = bodyValue; if(navigator.appName == 'Microsoft Internet Explorer') { if(document.getElementById('submit').disabled) { document.getElementById('submit').disabled=false; } else { document.getElementById('submit').disabled=true; } } return insertComment(form,true,function(){return showEditorialComment(nameValue, bodyValue)}); } else { alert('Please enter a valid Email below.'); form.elements[field.email].focus(); return false; } }

Source: http://www.atlanticcityweekly.com/food-and-drink/Revel-Spanning-the-Culinary-Gamut-144686655.html

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Stigma, Shame Can Worsen Depression in Lung Cancer Patients

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Dangerous online culture glorifies eating disorders

COLLEGE PARK, Md. ? Images of bony hipbones, concave stomachs, and quotes like "Nothing tastes as good as skinny feels" are popping up on social networks.

The images are part of a new Internet phenomenon - "Thinspiration" - that young women with eating disorders are using to support their unhealthy lifestyles.

Instead of seeking medical treatment, a growing community of anorexics and bulimics are using the Web to encourage each other to starve themselves, vomit after eating and over-exercise.

Social networks like Facebook, Pinterest and Tumblr are working to block Thinspiration content. Despite these efforts, the harmful images and quotes persist.

"These sites are started and frequented by people who are usually very deep into an eating disordered mindset," said Claire Mysko, a project consultant for the National Eating Disorder Association.

As many as 10 million women and 1 million men suffer from anorexia or bulimia in the United States, according to NEDA.

Thinspiration content, which advocates said prevents anorexics and bulimics from seeking treatment, includes images of extremely thin people and quotes encouraging eating disorders and excessive exercise. Some people with eating disorders also obsessively document their weight loss online.

"These websites, in a way, promote damaging behaviors, such as extreme weight loss, vomiting and using laxatives," said Scarlet Hemkes, creator of Proud2BMe, a site that promotes healthy body image and helps teenage girls recover from eating disorders.

Hemkes suffered from anorexia and bulimia for about 10 years before seeking treatment.

Before the advent of social networks and message boards, anorexics and bulimics generally kept their disease private. The Web has enabled them to seek encouragement and advice from others while remaining anonymous.

Strong communities that define themselves as "pro-ana" - for anorexics - and "pro-mia" - for bulimics - have become prominent.

"If you visit a website or blog like that you get the idea that you can only be successful as a female if you are skinny. That's cruel, stupid and very untrue," Hemkes said.

Though eating disorders affect people from all demographics, teenage girls make up the majority of these online communities, Mysko said.

"People who are suffering from eating disorders are feeling very isolated and very ashamed, so these communities provide a sense of community, but they do it in all the wrong ways. They're keeping people very stuck in dangerous and unhealthy behaviors," Mysko said.

Extreme thinness is often glorified in American popular culture. Images and descriptions of skinny women have always existed in books, magazines, and movies. But social media has made them more widely available.

Jenni Schaefer, who suffered from an eating disorder before thinspiration images appeared online, said the Web communities would have made her recovery more difficult.

"I never participated in these communities because when I got into recovery, it was 1999. So the Internet wasn't the big thing quite yet," Schaefer said. "I think that I could have easily been sucked into these communities and to some of these negative behaviors and the tips and tricks that they provide."

Peer influence - both online and off - can be a big driver of unhealthy eating habits.

American culture, and more specifically, the culture on college campuses, encourages young women to go to extremes to be thin, said Jane Jakubczak, the University of Maryland College Park's campus dietitian.

"Now you take that (culture) to social media sites, and in a way, you're expanding that infection. That may be a strong term, but I only see it growing," Jakubczak said.

Thinspiration images are rampant on Reddit, a fast-growing social network, which has multiple sub-reddits, or channels, dedicated to unhealthy images and quotes, including r/thinspo. The site also has a sub-reddit dedicated to eating disorders, r/EatingDisorders.

"I spent hours a day looking at diet tips, fad diets, pictures of skinny girls, low-cal recipes. And I constantly, constantly looked at pictures of food. Food I couldn't eat," said anorectic99, a redditor from Texas, in response to a query from Capital News Service.

Five months after discovering "pro-ana" blogs on Tumblr, anorectic99, who said she was 5 foot 5 inches tall, had dropped from 140 pounds to 110 pounds.

Capital News Service was unable to find members of thinspiration communities willing to talk on the record.

Websites and some social media companies are actively working to stop the spread of these messages, eating disorder awareness advocates said.

In addition to partnering with Proud2BMe, NEDA has also worked closely with Tumblr and Facebook to block users from posting thinspiration content on their networks.

"We're trying to raise awareness about the serious consequences of these sites and the ripple effect that's happening in social media," Mysko said.

People who suffer from anorexia are 18 times more likely to die early compared with people their age who do not suffer from the illness, according to a National Institute of Mental Health report.

"I think sometimes people feel like there is this love and support coming from these people online, when in reality, it's not love or support. It's people encouraging extremely negative behaviors, when - you could die," Schaefer said. "I know too many people who have died from anorexia and bulimia, and eating disorders in general."

Some thinspiration images and quotes are disguised as harmless motivation to get healthy and get to the gym. But advocates said everyone should embrace their individuality in terms of shape and size.

"Even for someone who doesn't have a tendency towards eating disorders, using someone else's body for motivation is still an unhealthy way of going about it," Jakubczak said.

"I think there are a lot of people out there who are really suffering who aren't clinically diagnosed with an eating disorder," Jakubczak said. "Those are the ones that these sites and the social media are nurturing and keeping them in that dissatisfied, dysfunctional thinking."

? Copyright (c) McClatchy-Tribune Information Services

Source: http://www.calgaryherald.com/health/Dangerous+online+culture+glorifies+eating+disorders/6379986/story.html

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Tips To Finding Happiness In Your Life

[unable to retrieve full-text content]Article from Article Directory and entitled Tips To Finding Happiness In Your Life - By Melinda Kingston. ... This article will give you some guidelines and tips when it comes to self help. A great way to help one's mood is to live ...

Source: http://www.articlesurge.com/Art/480047/140/Tips-To-Finding-Happiness-In-Your-Life.html

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S. Korea activists protest against Japan

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Source: http://news.yahoo.com/korea-activists-protest-against-japan-091750533.html

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Self-checking won't spot testicle cancer: doctor

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Dialog Semiconductor Extends Green VoIP IC Family to Address ...

KIRCHHEIM/TECK, Germany?(BUSINESS WIRE)?Dialog Semiconductor plc (FWB:DLG), a provider of highly integrated innovative power management, audio and short range wireless technologies, today announced a high performance VoIP phone chipset, the SC14453. The single chip processor enters Dialog?s VoIP portfolio as its flagship product and integrates hardware blocks for best-in-class audio, security and graphics functionality.

?Business user demands have meant that higher performance audio and higher resolution colour touch screens will be an integral part of next generation VoIP phones. The SC14453, with its best-in-class audio and exceptional graphics capabilities, is perfectly positioned to give our customers a competitive edge.?

The SC14453 has been created for mid and high end desktop phones and extends Dialog?s portfolio ? alongside Dialog?s SC14452 and SC14461 ? of award winning Green VoIP ICs, which now contains devices to support entry level through to high end designs.

?VoIP is fast becoming the de facto standard for business and enterprise communications,? said Dr. Asmund Tielens, Vice President and General Manager at Dialog. ?Business user demands have meant that higher performance audio and higher resolution colour touch screens will be an integral part of next generation VoIP phones. The SC14453, with its best-in-class audio and exceptional graphics capabilities, is perfectly positioned to give our customers a competitive edge.?

The on-board multicore VoIP processor delivers 590MIPS of computational power with industry-leading power consumption figures, and integrates stereo analogue codecs and a stereo Class D amplifier with 48kHz support, which along with Dialog?s acoustic echo cancellation and active noise reduction, combine to give best-in-class audio quality for crystal clear voice conversation.

The SC14453?s advanced audio DSPs and its symmetric / asymmetric cryptography accelerator can manage 8 simultaneous SRTP-secured IP calls, and its powerful graphic engine and LCD controller enable the output of fluid graphic user interfaces onto SVGA (800?600) touchscreen LCD displays. Dialog?s unique SafeKey feature based on Intrinsic-ID?s security IP block ensures bank-level security authentication of files and software. The SC14453 Green VoIP platform provides a high level of flexibility for wireless and wired extensions to DECT, CAT-iq, Bluetooth, WiFi, LTE, USB and Gigabit Ethernet.

The SC14453 is based on the highly efficient and ultra low power 32-bit MIPS? M14Kc? processor, has two user-programmable Gen3DSPs, an OpenVG1.1 graphic processing unit and comes in a 15x15mm, 228-pin LLGA package with standard and secure variants.

To reduce time to market Dialog offers a complete SC14453 VoIP development kit and the certified Rhea VoIP software platform, based on the popular open source operating system, Linux. The Dialog SC14453 Green VoIP processor is available now.

Note to editors:

Dialog Semiconductor creates highly integrated, mixed-signal integrated circuits (ICs) optimised for personal portable, low energy short-range wireless, lighting, display and automotive applications. The company provides flexible and dynamic support, world-class innovation and the assurance of dealing with an established business partner.

With its focus and expertise in energy efficient system power management, and now with the recent addition of low energy short range wireless and VoIP technology to the portfolio, Dialog brings decades of experience to the rapid development of ICs?for personal portable applications including smartphones, tablet PCs, digital cordless phones and gaming applications.

Dialog?s power management processor companion chips are essential for enhancing both the performance in terms of extended battery lifetime and the consumers? multimedia experience. With world-class manufacturing partners, Dialog operates a fabless business model.

Dialog Semiconductor plc is headquartered near Stuttgart with a global sales, R&D and marketing organisation. In 2011, it had approximately $527 million in revenue and was one of the fastest growing European public semiconductor companies. It currently has approximately 650 employees. The company is listed on the Frankfurt (FWB: DLG) stock exchange and is a member of the German TecDax index.

View article:
Dialog Semiconductor Extends Green VoIP IC Family to Address High End Phones

Rev :48

Related posts:

1. Dialog Semiconductor Plc.: Dialog Semiconductor Green VOIP ICs Adopted by Gigaset for its New Pro Range of Phones
2. Dialog Semiconductor Plc.: Dialog Semiconductor Extends Panasonic Relationship to Power Management and Digital Cordless Technology
3. Dialog Semiconductor VoIP Technology Adopted by VTech for S-Series Desktop Phones
4. Dialog Semiconductor Plc.: Dialog Semiconductor Power Management and Audio ICS Adopted by Samsung for Android Based Smartphones
5. Dialog Semiconductor Plc.: Dialog Semiconductor Schedules Q3 2011 Earnings Call For Tuesday 25 October 2011

Tags: business, delicious, family, feeds, green, industry, news, stumbleupon

Category: VoIP

Source: http://www.enterprisecommunicate.com/dialog-semiconductor-extends-green-voip-ic-family-to-address-high-end-phones/

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Xbox 360 apps now live for Comcast Xfinity TV, HBO Go and MLB.tv

Anxiously awaiting the arrival of those brand spanking new apps for your Xbox 360 console? Well, the wait is over. Video apps for Comcast Xfinity TV, HBO Go and MLB.tv have arrived on a number of consoles here at Engadget HQ. Major Nelson dropped the official word a little while ago, leaving you mere moments away from live and on demand television and baseball just in time for the start of the season. Keep in mind all three of these high profile applications feature Kinect integration -- but don't worry, you won't be forced to swing any bats in your living room. If you're looking for more info, details on the HBO Go and MLB.tv offerings await in the PR below.

Continue reading Xbox 360 apps now live for Comcast Xfinity TV, HBO Go and MLB.tv

Xbox 360 apps now live for Comcast Xfinity TV, HBO Go and MLB.tv originally appeared on Engadget on Tue, 27 Mar 2012 12:07:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2012/03/27/xbox-360-apps-now-live-for-comcast-xfinity-tv-hbo-go-and-mlb-tv/

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Source: http://www.insuranceadviceblog.com/get-the-best-price-for-vision-student-insurance

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Susan Blumenthal, M.D.: World Tuberculosis Day 2012: Stopping Tuberculosis in Our Lifetimes

By Susan Blumenthal, M.D, M.P.A.
Written in collaboration with Yoonhee Ha, M.Sc.

This Saturday, March 24 is World Tuberculosis Day, marking the 130th anniversary of Dr. Robert Koch's discovery of Mycobacterium tuberculosis, the microbe that causes tuberculosis. This year, the Stop TB Partnership, an international collaborative of governmental and non-governmental organizations, the private sector, and others dedicated to fighting tuberculosis, has adopted "Stop TB in My Lifetime" as its theme for World Tuberculosis Day. Yet, nearly a century and a half after Koch's discovery, stopping tuberculosis in our lifetimes is a formidable challenge. A $1.7 billion dollar shortfall for the Global Fund to Fight AIDS, TB and Malaria over the next five years means that 3.4 million patients may go untreated. This could reverse the important gains that have been made over the past years in the fight against this disease. The Global Fund provides 80 percent of external resources for TB eradication and treatment. Since this public/private partnership was established in 2002, the organization has helped detect and treat 8.6 million cases of TB [1].

TB is one of the most widespread infectious illnesses in the world -- with an estimated one-third of people globally infected with the bacteria that causes TB according to the World Health Organization (WHO). In 2010, the World Health Organization (WHO) reported that there were an alarming 8.8 million new cases of active tuberculosis and 1.4 million deaths caused by this disease, making it the eighth leading cause of death globally [2,3]. However, these numbers represent a decline in new cases since 2005. With 95 percent of TB deaths occurring in developing countries, tuberculosis is a public health problem that disproportionately affects the poor and young adults in their most productive years [4]. Furthermore, there were 9.7 million orphaned children as a result of their parents' death from TB.

Significantly fewer people die of tuberculosis in developed countries, but the disease nonetheless remains a health threat in the United States, with more than 10,521 cases reported in 2011 [5,1]. TB is a public health tragedy, given that it is both preventable and curable. However, this week there was some good news: TB infections in America have dropped to record lows, falling 6.4 percent in 2011, but still missing a national target for eliminating the disease. TB rates are 12 times higher among people living in the U.S. who were born outside the country. Compared with whites, TB rates were seven times higher for Hispanics, eight times higher for blacks, and 25 times higher for Asians in America last year. Four states -- California, Texas, New York, and Florida -- account for nearly half of all TB cases in the United States. According to a recent CDC report, unless circumstances change significantly, the U.S. will not be able to eradicate TB until 2100.

The symptoms of tuberculosis include coughing, chest pain, fatigue, fever, weight loss, chills, night sweats, and loss of appetite. While TB most often affects the lungs, it can also affect the brain, kidneys, or spine. The disease can spread when an individual with active tuberculosis -- a disease state characterized by actively dividing bacteria -- coughs, sneezes, talks, or spits, releasing droplets containing M. tuberculosis into the air. If other people inhale these droplets, they may acquire the disease. Without treatment, individuals with active TB will infect an average of 10 to 15 people each year, and can ultimately die from the disease. Individuals with latent tuberculosis -- characterized by non-dividing bacteria -- are symptomless and unable to infect others, but they remain at risk of developing active disease if they are not treated. It is estimated that one-third of the world's population currently has latent tuberculosis [6].

Significant progress has been made in the fight against TB in recent decades. Since 1990, there has been a 40 percent decline in the global death rate for this disease, and the world was on track until the recent funding shortfalls to achieve the Millennium Development Goal 6 target that aims to halt and reverse the tuberculosis incidence rate by 2015 [3,4].

One major advance has been the implementation of Directly Observed Therapy Short-Course (DOTS), a multi-pronged tuberculosis control strategy best known for its use of health care workers to supervise the administration of TB therapy. This approach has dramatically improved treatment rates and patient survival. DOTS has five key components: 1) sustained political and financial commitment; 2) diagnosis by quality-ensured sputum-smear microscopy; 3) standardized short-course anti TB treatment given under direct and supportive observation; 4) a regular, uninterrupted supply of high quality anti-TB drugs; and 5) standardized treatment and reporting. Globally, by 2007, 99 percent of all cases of TB reported to WHO were being treated in DOTS programs. In 2009, DOTS had a treatment success rate of 87 percent -- its highest level to date. Since 1995, 46 million people have been successfully treated and up to 6.8 million lives have been saved through DOTS and the Stop TB Strategy. And this month, the World Health Organization (WHO) announced that its integrated prevention, diagnosis, and treatment efforts for tuberculosis and the human immunodeficiency virus (HIV) prevented an estimated 910,000 deaths in six years [7].

While these efforts have made a lifesaving difference for many, much more remains to be done. Here is why:

• Tuberculosis prevention is limited by the lack of an effective vaccine. The existing Bacillus Calmette-Gu?rin (BCG) vaccine has limited success in preventing tuberculosis infection. When successful, protection is estimated to last around 15 years. Furthermore, the vaccine has been shown to cause potentially fatal infection when given to HIV-positive adults or to children with weak immune systems [9].
• Many resource-poor countries lack the necessary infrastructure, equipment, and trained personnel needed to accurately diagnose tuberculosis and differentiate between drug-resistant strains. As a result, many infected people remain undiagnosed or receive non-effective treatments. The WHO's recent endorsement of the Xpert MTB/RIF, a diagnostic test that is capable of detecting M. tuberculosis and resistance to the drug rifampicin in two hours, represents a major step forward in reducing the time required for diagnosis and detection of multi-drug resistant (MDR) tuberculosis (the type that is resistant to the two most powerful first line TB drugs). However, there is still a need for additional rapid diagnostic tests that are both accurate and affordable for use in the developing world.
• Existing treatment regimens require patients with active tuberculosis to take multiple drugs for months at a time, making treatment adherence challenging. This, along with the prescribing of incorrect drugs, has contributed to the emergence and spread of MDR and extensively drug-resistant (XDR) tuberculosis. In 2010, there was an estimated prevalence of 650,000 cases of multidrug-resistant TB (MDR-TB) and in 2008, 150,000 deaths annually. Because these types of tuberculosis are very difficult and costly to treat, they provide significant challenges to TB control efforts.
• TB control efforts are also complicated by the co-existence of tuberculosis and HIV/AIDS. Tuberculosis is the leading cause of death for people with HIV/AIDS worldwide. Because people with HIV/AIDS have weakened immune systems, they have a 20-37 times greater risk of developing active tuberculosis than people without HIV/AIDS [8]. Yet rates of TB testing among HIV patients and provision of ARV therapy to co-infected individuals remains low.
• Current projected shortfalls in funding are jeopardizing the progress that has been made in tuberculosis care and control. Worldwide, the share of domestic funding for TB provided by affected countries rose to 86 percent. But most low-income countries still depend on external funding with The Global Fund to Fight AIDS, Tuberculosis and Malaria -- an international public-private funding institution to which the United States is the largest contributor -- providing 82 percent of international TB support in 2012. Other important sources of funding include President Obama's Global Health Initiative (TB is one of GHI's six focus areas), PEPFAR, and the Gates Foundation [3, 9]. In March 2010, in response to Congressional reporting requirements to develop a coordinated approach to global TB, several U.S. government agencies released a joint TB strategy to accelerate the diagnosis, treatment, and prevention of TB; scale up prevention and treatment of MDR-TB; expand coverage of interventions for TB-HIV co-infections in coordination with PEPFAR programs; and strengthen national health systems. The United States currently provides bilateral TB assistance to 40 countries. Alarmingly, due to the current economic crisis, U.S. funding for PEPFAR may be cut. Furthermore, the Global Fund to Fight AIDS, Tuberculosis and Malaria has announced that due to limited resources this year, it would postpone all new program grants until at least 2014. Overall funding for tuberculosis is expected to total $4.4 billion in 2012, which falls $1.7 billion short of projected needs. At $0.6 billion, funding for MDR tuberculosis faces a resource gap of $200 million. This lack of resources jeopardizes the gains that have made against this disease in recent years [1].

Addressing each of these challenges will be essential to eliminating tuberculosis in the years ahead. Many of the tools currently used for TB prevention, diagnosis, and treatment are antiquated and have limited success rates. Given the toll that TB takes on the world's population, an effective vaccine, rapid diagnostic tests, shortened, effective treatment regimens, and more research on the illness are required. That's why increased funding is urgently needed to develop 21st-century approaches. In order to ensure that new tools are developed and today's treatments are provided, governments must prioritize tuberculosis as a public health priority and close the projected gaps in domestic and international funding. In areas with a high burden of HIV/AIDS, scaling up joint HIV/TB prevention, diagnosis, and treatment activities will play a critical role in reducing tuberculosis and HIV-related deaths.

Nearly one and a half centuries have passed since Koch's discovery of the causative agent of tuberculosis; significant progress has been made with declining death rates globally but the disease nonetheless remains a leading killer in the developing world and a public health threat in the United States as well. As UN Secretary-General Ban Ki-moon recently underscored, intensified global solidarity is needed. "Countries must implement policies that not only raise awareness about the issue but provide accessible health care to their citizens." For those affected by the disease, stopping tuberculosis cannot wait a lifetime.

To learn more, visit:
World Health Organization -- http://www.who.int/tb/en
Stop TB Partnership -- http://www.stoptb.org
Centers for Disease Control and Prevention (CDC) -- http://www.cdc.gov/tb

Rear Admiral Susan Blumenthal, M.D., M.P.A. (ret.) is the Public Health Editor of the Huffington Post. She is the Director of the Health and Medicine Program at the Center for the Study of the Presidency and Congress in Washington, D.C., a Clinical Professor at Georgetown and Tufts University Schools of Medicine, Chair of the Global Health Program at the Meridian International Center, and Senior Policy and Medical Advisor at amfAR, The Foundation for AIDS Research. Dr. Blumenthal served for more than 20 years in senior health leadership positions in the Federal government in the Administrations of four U.S. Presidents, including as Assistant Surgeon General of the United States, the first Deputy Assistant Secretary of Women's Health, as a White House Advisor on Health, and as Chief of the Behavioral Medicine and Basic Prevention Research Branch at the National Institutes of Health. Admiral Blumenthal has received numerous awards including honorary doctorates and has been decorated with the highest medals of the US Public Health Service for her pioneering leadership and significant contributions to advancing health in the United States and worldwide. She is the recipient of the 2009 Health Leader of the Year Award from the Commissioned Officers Association and was named as a Rock Star of Science by the Geoffrey Beene Foundation and GQ magazine.

Yoonhee Ha, M.Sc., is an M.D.-Ph.D. candidate, Paul and Daisy Soros Fellow for New Americans, and P.E.O. Scholar at the University of Pennsylvania Perelman School of Medicine. She was a Marshall and Truman Scholar and completed graduate studies in public health at London School of Hygiene and Tropical Medicine.

For more articles by Susan Blumenthal, M.D., M.P.A., click here.

For more healthy living health news, click here.

References
[1] Reuters: "Funding cuts put 3.4 million TB patients at risk: NGOS."
http://uk.reuters.com/article/2012/03/23/us-tuberculosis-funding-idUKBRE82M00A20120323 Accessed 23 March 2012.
[2] World Health Organization: The top 10 causes of death. June 2011. http://www.who.int/mediacentre/factsheets/fs310/en/index.html. Accessed 7 March 2012.
[3] World Health Organization: Global tuberculosis control 2011. October 2011. http://www.who.int/tb/publications/global_report/2011/gtbr11_full.pdf. Accessed 19 February 2012.
[4] World Health Organization: Tuberculosis facts 2011/2012. 2011. http://www.who.int/tb/publications/2011/factsheet_tb_2011.pdf. Accessed 19 February 2012.
[5] Centers for Disease Control and Prevention: Reported tuberculosis in the United States, 2010. October 2011. http://www.cdc.gov/tb/statistics/reports/2010/pdf/report2010.pdf. Accessed 19 February 2012.
[6] World Health Organization: World TB Day. http://www.who.int/mediacentre/events/annual/world_tb_day/en/index.html. Accessed 19 February 2012.
[7] World Health Organization: More than 900 000 lives saved by protecting people living with HIV from TB. 2 March 2012. http://www.who.int/mediacentre/news/notes/2012/tb_hiv_guide_20120302/en/index.html. Accessed 4 March 2012.
[8] World Health Organization: Guidelines for intensified tuberculosis case-finding and isoniazid preventive therapy for people living with HIV in resource-constrained settings. 1 May 2011. http://whqlibdoc.who.int/publications/2011/9789241500708_eng.pdf. Accessed 12 March 2012.
[9] Congressional Research Service: Kendall, A.E. U.S. response to the global threat of tuberculosis: basic facts. 5 January 2012. Accessed 18 March 2012.

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Source: http://www.huffingtonpost.com/susan-blumenthal/tuberculosis_b_1375689.html

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Lawyer says French gunman's mother is released

PARIS (AP) ? Authorities investigating France's deadly shooting rampage have released the mother of the Islamist fanatic blamed for the killings but continue to hold his older brother and the older brother's girlfriend, officials said Saturday.

Police are trying to determine whether 24-year-old Mohamed Merah had any help in carrying out the execution-style murders of seven people that have shocked France and refocused attention on the threat of radical Muslim terrorists.

Merah's brother, Abdelkader, was flown to Paris for further questioning Saturday, along with his girlfriend, but a lawyer for Merah's mother, 55-year-old Zoulika Aziri, said she had been released without charge. Jean-Yves Gougnaud told reporters in the southern French city of Toulouse that Aziri's world had been "turned upside down."

"She is devastated," he told reporters after her release. "At no time could she have imagined that her son was the one who did it."

Aziri was freed late Friday from a police station in Toulouse, a judicial official said on condition of anonymity because the information wasn't cleared for public release.

Mohamed Merah, who claimed allegiance to al-Qaida, died in a hail of gunfire Thursday after a dramatic 32-hour standoff with police at his apartment in Toulouse. At one point, police brought his mother to the scene, but she refused to urge her son to surrender, officials said.

Merah had filmed himself carrying out attacks in southern France that began March 11 and killed three Jewish schoolchildren, a rabbi and three French paratroopers with close-range shots to the head, prosecutors say. Another Jewish student and a paratrooper were wounded, and five police officers were injured trying to dislodge Merah from the apartment.

Investigators are trying to figure out whether Merah, a Frenchman of Algerian descent, acted alone.

Key questions include how Merah, described by French intelligence boss Ange Mancini as "a little failure from the suburbs," was able to amass an arsenal of weapons ? including an Uzi sub-machinegun ? and rent a car, despite having no clear source of income.

Mancini told French broadcaster BFMTV that Merah told police during the siege that he bought the weapons for 20,000 euros, using money he acquired through break-ins and holdups.

Mancini said he believed that Merah was telling the truth about that, but suggested that forensic police would be examining the guns for clues as to where Merah got them.

"The weapons, too, will talk," Mancini said.

Merah had claimed that neither his mother nor his brother knew of his plans, but police union spokesman Christophe Crepin told reporters that detectives have already gathered evidence to suggest that Abdelkader may have helped his brother carry out the shootings.

Asked what police had on the brother, Crepin said there was evidence to suggest that Abdelkader Merah had "furnished means (and) worked as an accomplice."

Crepin refused to comment further, saying it was for a judge to decide what charges, if any, to bring. Under French law if either of the two continue to be held beyond the weekend, preliminary charges will have to be filed.

Abdelkader had already come under police radar, according to officials. He was questioned several years ago about alleged links to a network sending Toulouse-area youths to Iraq, but no action was brought against him at the time.

Back in the southern French city of Toulouse, where Merah held out in an apartment building for more than a day against one of France's most elite police units, residents were beginning to return home to inspect the damage.

Video footage shot by police of the inside of Merah's apartment showed a shattered three-room residence strewn with debris from the fighting and gaping bullet holes in the walls.

Building resident Farida Bohama was quoted by France's Le Figaro newspaper as saying nothing would ever be the same.

"I really want to move," she said.

(This version CORRECTS Corrects police union spokesman's first name to Christophe. Changes approach, upgrades attribution. Adds mother's lawyer's comment, photos.)

Source: http://news.yahoo.com/lawyer-says-french-gunmans-mother-released-130311622.html

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Are You Building A Company, Or Just Your Credentials?

Y Combinator recently announced that for the next batch, the incubator will accept applications from groups and individuals without an idea. That same night, I received a breathless call from a friend currently finishing up his MBA at an elite east coast business school, asking me for help putting together his ?Without Idea? Y Combinator application. This friend is smart, dynamic, and an all-around great person. But he?s not someone I consider to be entrepreneurial. He was a management consultant at a big firm for years before business school, and loved it. He?s the first to admit that his interest in startups conveniently coincided with the premier of The Social Network a few years back. So on the call, I asked him, ?why jump into entrepreneurship now. You are someone who likes to be on a stable path. Why do you suddenly want to start a startup?? His answer: ?Even if the startup ends up going nowhere, graduating from Y Combinator would be such a great credential.?

Source: http://feedproxy.google.com/~r/Techcrunch/~3/opNe9-QmuxA/

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